Research

Publications

Original Manuscripts

  • Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity

    Tucker LB, Niemietz I, Mangat P, Belen M, Tekano J, Cabral DA, Morishita KA, Guzman J, Human A, Houghton K, Chan M, Petty RE, Sundqvist M, Brown KL.

    (2021) Clinical and Experimental Rheumatology Manuscript #14653, accepted with minor revisions June 2021.

  • Latent gamma herpes virus exacerbates arthritis and requires age-associated B cells

    Mouat I, Morse Z, Shanina I, Brown KL, and Horwitz M.

    (2021) eLife In Press. PubMed

  • Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions

    Sävman K, Wang W, Rafati AH, Svedin P, Nair S, Golubinskaya V, Brown KL, Karlsson A, and Mallard C.

    (2021) Developmental Neuroscience In Press. PubMed

  • Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels

    Gill EE, Smith ML, Gibson KM, Morishita KA, Lee AHY, Falsafi R, Graham J, Foell D, Benseler S, Ross C, Luqmani R, Cabral DA, Hancock REW, and Brown KL on behalf of the PedVas Initiative Investigators.

    (2021) Frontiers in Immunology 12: 638571. PubMed

  • Autoantibodies against lysosome associated membrane protein-2 (LAMP-2) in pediatric chronic systemic vasculitis

    Gibson KM, Kain R, Luqmani R, Ross CJ, Cabral DA, and Brown KL on behalf of the PedVas Initiative Investigators.

    (2021) Frontiers in Immunology 11: 624758. PubMed

  • Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

    Amarilyo G, Rothman D, Manthiram K, Edwards KM, Li SC, Marshall GS, Yildirim-Toruner C, Haines K, Ferguson PJ, Lionetti G, Cherian J, Zhao Y, DeLaMora P, Syverson G, Nativ S, Twilt M, Michelow IC, Stepanovskiy Y, Thatayatikom A, Harel L, Akoghlanian S, Tucker L, Marques MC, Srinivasalu H, Propst EJ, Licameli GR, Dedeoglu F, and Lapidus S; CARRA PFAPA Consensus Treatment Plan Workgroup.

    (2020) Pediatric Rheumatology 18(1): 31. PubMed

  • Hyaluronan primes the oxidative burst in human neutrophils

    Niemietz I, Moraes AT, Sundqvist M, and Brown KL.

    (2020) Journal of Leukocyte Biology 108(2): 705-713. PubMed

  • Adenosine Deaminase 2 activity negatively correlates with age during childhood

    Bowers SM, Gibson KM, Cabral DA, and Brown KL.

    (2020) Pediatric Rheumatology 18(1): 54. PubMed

  • Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants

    Tucker LB , Lamot L, Niemietz I, Chung BK, Cabral DA, Houghton K, Petty RE, Morishita KA, Rice GI, Turvey SE, Gibson WT, and Brown KL.

    (2019) Pediatric Rheumatology 17(1): 70. PubMed

  • Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems

    Lamot L, Niemietz I, and Brown KL.

    (2019) BMC Research Notes 12(1): 511. PubMed

  • Identification of novel ADA2/CECR1 gene variants and varied clinical phenotype in pediatric vasculitis

    Gibson KM, Morishita K, Dancey P, Moorehead P, Drogmoller B, Shan X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung R, Shenoi S, Bohm M, Rosenberg A, Ross CR, Cabral DA, Brown KL on behalf of the PedVas study group.

    (2019) Arthritis & Rheumatology In Press. Apr 22. PubMed

  • Monocyte-derived interleukin-1 as the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: Implications for the pathogenesis of Kawasaki Disease

    Armaroli G, Verweyen E, Pretzer C, Kessel K, Hirono K, Ichida F, Okabe M, Cabral DA, Foell D, Brown KL and Kessel C.

    (2019) Arthritis & Rheumatology 71(5): 792-804. PubMed

  • S100A12 and common inflammatory markers improve assessment of disease activity in a PedVas cohort of childhood systemic vasculitis

    Brown KL, Lubieniecki JM, Armaroli G, Kessel K, Gibson KM, Graham J, Liu D, Hancock REW, Ross CJ, Benseler S, Luqmani R, Cabral DA, Foell D and Kessel C on behalf of the PedVas study group.

    (2018) Frontiers in Pediatrics 6: 341. PubMed

  • Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes

    Sundqvist M, Christenson K, Björnsdottir H, Osla V, Karlsson A, Dahlgren C, Speert DP, Anders F, Bylund J* and Brown KL*. (* authors contributed equally).

    (2017) Frontiers Immunology 8: 1828. PubMed

  • Measles Lymphadenopathy in a Child With PFAPA Syndrome

    Jefferson T, Brown KL, Hiebert J, Al-Rawahi GN, Moxham JP, Krajden M, Jassem AN and Tucker LB.

    (2017) Pediatric and Developmental Pathology 21(5): 497-501. PubMed

  • Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey

    Westwell-Roper, C, Lubieniecka JM, Brown KL, Morishita KA, Mammen C, Wagner-Weiner L, Yen E, Li, SC, O’Neil K, Lapidus SK, Brogan P, Cimaz R, Cabral DA for the ARChiVe Investigators Network within the PedVas initiative.

    (2017) Pediatric Rheumatology Online Journal 15(1): 61. PubMed

  • The Importance of Considering Monogenic Causes of Autoimmunity: A Somatic Mutation in KRAS Causing Pediatric Rosai-Dorfman Syndrome and Systemic Lupus Erythematosus

    Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE.

    (2016) Clinical Immunology 175: 143-146. PubMed

  • Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxia-ischemic brain injury

    Hellström Erkenstam N, Fleiss B, Smith P, Wang W, Boström M, Gressens P, Hagberg H, Brown KL, Sävman K, Mallard C.

    (2016) Frontiers in Cellular Neuroscience 10: 286. PubMed

  • Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages

    Dong Y, Arif AA, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P.

    (2016) Scientific Reports 6: 36928. PubMed

  • Innate defence regulatory peptide protects against neonatal brain injury

    Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Mallard C*, Brown KL*. (* authors contributed equally).

    (2014) Annals of Neurology 75: 395. PubMed

  • Increased intracellular oxygen radical production in neutrophils during febrileepisodes of PFAPA syndrome

    Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Fasth A, Berg S, Karlsson A*, Brown KL*. (* authors contributed equally).

    (2013) Arthritis & Rheumatism 65: 2971-2983. PubMed

  • On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL, Wekell P, Karlsson A, Berg S.

    (2011) Proc. Natl. Acad. Sci. U.S.A 108: E525. PubMed

  • Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and interleukin activated macrophages

    Ruffell B, Poon GF, Lee SS, Brown KL, Tjew S-L, Cooper J and Johnson P.

    (2011) J. Biol. Chem. 286: 19179-19190. PubMed

  • Host defence peptide LL-37 selectively reduces pro-inflammatory macrophages responses

    Brown KL*, Poon GF*, Birkenhead D, Pena OM, Falsafi R, Dahlgren C, Karlsson A, Bylund J, Hancock REW and Johnson P. (* authors contributed equally).

    (2011) J. Immunol. 186: 5497-5505. PubMed

  • Galectin-3 aggravates joint inflammation and destruction in antigen-induced arthritis

    Forsman H, Islander U, Andréasson E, Andersson A, Önnheim K, Karlström A, Sävman K, Magnusson M, Brown KL and Karlsson A.

    (2011) Arthritis & Rheumatism 63: 445-454. PubMed

  • Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL*, Wekell P*, Osla V, Sundqvist M, Sävman K, Fasth A, Karlsson A, Berg S. (* authors contributed equally).

    (2010) BMC Pediatrics 10: 65. PubMed

  • Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

    Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Finlay BB, Turvey SE, Speert DP and Hancock REW.

    (2010) J. Transl. Med. 8: 6-17. PubMed

  • G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9

    Gong J-H, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, Cheung CY, Falsafi R, Brinkman FS, Bowdish DM and Hancock REW.

    (2010) Cellular Immunology 261: 105-113. PubMed

  • Divergent effects on phagocytosis by macrophage-derived oxygen radicals

    Brown KL, Christenson K, Karlsson A, Dahlgren C, Bylund J.

    (2009) J. Innate Immunity 1: 592-598. PubMed

  • Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

    Amid C, Rehaume LM, Brown KL, Gilbert JGR, Dougan G, Hancock REW and Harrow JL.

    (2009) BMC Genomics 10: 606-618. PubMed

  • Galectin-3 functions as an opsonin and enhances macrophage clearance of apoptotic neutrophils

    Karlsson A, Matlak M, Christenson K, Björstad Å, Brown KL, Telemo E, Salomonsson E, Leffler H and Bylund J.

    (2009) Glycobiology 9: 16-20. Brief Communication. PubMed

  • ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

    Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott M, Falsafi R, Hancock R and Speert DP.

    (2008) Clin. Immunol. 129: 90-102. PubMed

  • The host defence peptide LL-37 selectively permeabilises apoptotic leukocytes

    Björstad Å, Askarieh G, Brown KL, Christenson K, Önnheim K, Hsin-Ni L, Teneberg S, Maier O, Hoekstra D, Dahlgren C, Davidson DJ and Bylund J.

    (2008) J. Antimicrobial Agents and Chemotherapy 53: 1027-1038. PubMed

  • Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NFκB

    Bylund J, MacDonald KL, Brown KL, Mydel P, Collins VL, Hancock R, and Speert DP.

    (2007) Eur. J. Immunol. 37(4): 1087-96. PubMed

  • IRAK-4 mutation (Q293X): rapid detection, and characterization of defective post-transcriptional TLR/IL1R responses in human myeloid and non-myeloid cells

    Davidson DJ, Currie AJ, Bowdish DME, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Devon RE, Hancock R and Speert DP.

    (2006) J. Immunol. 177: 8202-11. PubMed

  • Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37

    Brown KL*, Mookherjee N*, Bowdish DME, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers J-P, Bryan J, Brinkman FSL and Hancock R. (* authors contributed equally).

    (2006) J. Immunol. 176: 2455-64. PubMed

  • Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide

    Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu J, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FSL, Hokamp K, Potter A, Babiuk LA, Griebel PJ and Hancock R.

    (2006) J. Leukoc. Biol. 80(6): 1563-74. PubMed