Research

Publications

  • Behcet’s Syndrome - Recent advances to aid diagnosis

    Hilmi Akbaba T, Ekinci M, Ilksen Çolpak I, Brown KL, Karadăg Ö, Balci-Peynircioglu B.

    (2023) Clinical and Experimental Medicine. Oct 28. doi: 10.1007/s10238-023-01226-7. Epub ahead of print. PubMed

  • Anti-LAMP-2 antibody seropositivity in children with primary systemic vasculitis affecting medium and large blood vessels

    Akbaba T*, Toor K*, Mann S, Gibson KM, Balci-Peynircioglu B, Cabral DA, Morishita KA, Brown KL (* authors contributed equally).

    (2023) Frontiers in Immunology. Under review. July 2023.

  • Hyaluronan promotes intracellular ROS production and apoptosis in TNFα-stimulated neutrophils

    Niemietz I and Brown KL.

    (2023) Frontiers Immunology. 14: 1032469. PubMed

  • Elevated adenosine deaminase 2 (ADA2) enzyme activity at the onset of chronic Graft-versus-Host Disease in children

    Bowers SM, Ng B, Abdossamadi S, Kariminia A, Cabral DA, Cuvelier GDE, Shultz KR, and Brown KL.

    (2023) Transplantation and Cellular Therapy. 29(5): 303.e1-202.e9. PubMed

  • HLA-DBP1 is associated with ANCA-associated vasculitis in children

    Gibson KM*, Drogemoller BI*, Foell D, Benseler S, Graham J, Hancock REW, Luqmani R, Cabral DA, Brown KL**, and Ross CJ** on behalf of the PedVas investigators network (* and ** authors contributed equally).

    (2023) Arthritis & Rheumatology. 75(6): 1048-1057. PubMed

  • Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates Type I IFN responsive gene expression

    Bowers SM, Sundqvist M, Dancey P, Cabral DA and Brown KL.

    (2022) Frontiers Immunology. 13: 995191. doi: 10.3389/fimmu.2022.995191. PubMed

  • Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity

    Tucker LB, Niemietz I, Mangat P, Belen M, Tekano J, Cabral DA, Morishita KA, Guzman J, Human A, Houghton K, Chan M, Petty RE, Sundqvist M, Brown KL.

    (2021) Clinical and Experimental Rheumatology. 39(5): Suppl. 132. PubMed

  • Latent gamma herpes virus exacerbates arthritis and requires age-associated B cells

    Mouat I, Morse Z, Shanina I, Brown KL, and Horwitz M.

    (2021) eLife. 10: e67024. PubMed

  • Galectin-3 modulates microglia inflammation in vitro but not neonatal brain injury in vivo under inflammatory conditions

    Sävman K, Wang W, Rafati AH, Svedin P, Nair S, Golubinskaya V, Brown KL, Karlsson A, and Mallard C.

    (2021) Developmental Neuroscience. 43(5): 296-311. PubMed

  • Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels

    Gill EE, Smith ML, Gibson KM, Morishita KA, Lee AHY, Falsafi R, Graham J, Foell D, Benseler S, Ross C, Luqmani R, Cabral DA, Hancock REW, and Brown KL on behalf of the PedVas Initiative Investigators.

    (2021) Frontiers in Immunology. 12: 638571. PubMed

  • Autoantibodies against lysosome associated membrane protein-2 (LAMP-2) in pediatric chronic systemic vasculitis

    Gibson KM, Kain R, Luqmani R, Ross CJ, Cabral DA, and Brown KL on behalf of the PedVas Initiative Investigators.

    (2021) Frontiers in Immunology. 11: 624758. PubMed

  • Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

    Amarilyo G, Rothman D, Manthiram K, Edwards KM, Li SC, Marshall GS, Yildirim-Toruner C, Haines K, Ferguson PJ, Lionetti G, Cherian J, Zhao Y, DeLaMora P, Syverson G, Nativ S, Twilt M, Michelow IC, Stepanovskiy Y, Thatayatikom A, Harel L, Akoghlanian S, Tucker L, Marques MC, Srinivasalu H, Propst EJ, Licameli GR, Dedeoglu F, and Lapidus S; CARRA PFAPA Consensus Treatment Plan Workgroup.

    (2020) Pediatric Rheumatology. 18(1): 31. PubMed

  • Anti-neutrophil cytoplasmic antibodies (ANCA): Antigen interactions and downstream effects

    Sundqvist M, Gibson KM, Bowers SM, Niemietz I, and Brown KL.

    (2020) Journal of Leukocyte Biology. 108(2): 617-626. PubMed

  • Hyaluronan primes the oxidative burst in human neutrophils

    Niemietz I, Moraes AT, Sundqvist M, and Brown KL.

    (2020) Journal of Leukocyte Biology. 108(2): 705-713. PubMed

  • Adenosine Deaminase 2 activity negatively correlates with age during childhood

    Bowers SM, Gibson KM, Cabral DA, and Brown KL.

    (2020) Pediatric Rheumatology. 18(1): 54. PubMed

  • Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants

    Tucker LB , Lamot L, Niemietz I, Chung BK, Cabral DA, Houghton K, Petty RE, Morishita KA, Rice GI, Turvey SE, Gibson WT, and Brown KL.

    (2019) Pediatric Rheumatology. 17(1): 70. PubMed

  • Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems

    Lamot L, Niemietz I, and Brown KL.

    (2019) BMC Research Notes. 12(1): 511. PubMed

  • Periodic fever Syndromes: beyond the single gene paradigm

    Westwell-Roper C, Niemietz I, Tucker LB and Brown KL.

    (2019) Pediatric Rheumatology Online Journal. 17(1): 22. PubMed

  • Identification of novel ADA2/CECR1 gene variants and varied clinical phenotype in pediatric vasculitis

    Gibson KM, Morishita K, Dancey P, Moorehead P, Drogmoller B, Shan X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung R, Shenoi S, Bohm M, Rosenberg A, Ross CR, Cabral DA, Brown KL on behalf of the PedVas study group.

    (2019) Arthritis & Rheumatology. 71(10): 1747-1755. PubMed

  • The value of creativity for enhancing translational ecologies, insights, and discoveries

    Goeltzenleuchter B, van Suchtelen A, Brown KL and Grompone G.

    (2019) Front. Psychol.. 10: 951. PubMed

  • Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases. Review

    Lamot L, Niemietz I and Brown KL.

    (2019) Clinical and Experimental Rheumatology. 37(6): 1077-1083. PubMed

  • Monocyte-derived interleukin-1 as the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: Implications for the pathogenesis of Kawasaki Disease

    Armaroli G, Verweyen E, Pretzer C, Kessel K, Hirono K, Ichida F, Okabe M, Cabral DA, Foell D, Brown KL and Kessel C.

    (2019) Arthritis & Rheumatology. 71(5): 792-804. PubMed

  • S100A12 and common inflammatory markers improve assessment of disease activity in a PedVas cohort of childhood systemic vasculitis

    Brown KL, Lubieniecki JM, Armaroli G, Kessel K, Gibson KM, Graham J, Liu D, Hancock REW, Ross CJ, Benseler S, Luqmani R, Cabral DA, Foell D and Kessel C on behalf of the PedVas study group.

    (2018) Frontiers in Pediatrics. 6: 341. PubMed

  • Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes

    Sundqvist M, Christenson K, Björnsdottir H, Osla V, Karlsson A, Dahlgren C, Speert DP, Anders F, Bylund J* and Brown KL*. (* authors contributed equally).

    (2017) Frontiers Immunology. 8: 1828. PubMed

  • Measles Lymphadenopathy in a Child With PFAPA Syndrome

    Jefferson T, Brown KL, Hiebert J, Al-Rawahi GN, Moxham JP, Krajden M, Jassem AN and Tucker LB.

    (2017) Pediatric and Developmental Pathology. 21(5): 497-501. PubMed

  • Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey

    Westwell-Roper, C, Lubieniecka JM, Brown KL, Morishita KA, Mammen C, Wagner-Weiner L, Yen E, Li, SC, O’Neil K, Lapidus SK, Brogan P, Cimaz R, Cabral DA for the ARChiVe Investigators Network within the PedVas initiative.

    (2017) Pediatric Rheumatology Online Journal. 15(1): 61. PubMed

  • The Importance of Considering Monogenic Causes of Autoimmunity: A Somatic Mutation in KRAS Causing Pediatric Rosai-Dorfman Syndrome and Systemic Lupus Erythematosus

    Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE.

    (2016) Clinical Immunology. 175: 143-146. PubMed

  • Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxia-ischemic brain injury

    Hellström Erkenstam N, Fleiss B, Smith P, Wang W, Boström M, Gressens P, Hagberg H, Brown KL, Sävman K, Mallard C.

    (2016) Frontiers in Cellular Neuroscience. 10: 286. PubMed

  • Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages

    Dong Y, Arif AA, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P.

    (2016) Scientific Reports. 6: 36928. PubMed

  • Pediatric Vasculitis: Advances in Treatment

    Morishita K, Brown KL, Cabral DA.

    (2015) Curr. Opin. Rheum.. 27: 493-499. PubMed

  • The where, when, how and why of hyaluronan binding by immune cells

    Lee-Sayer SS, Dong Y, Arif AA, Olsson M, Brown KL, Johnson P.

    (2015) Front. Immunol.. 6: 150. PubMed

  • Innate defence regulatory peptide protects against neonatal brain injury

    Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Mallard C*, Brown KL*. (* authors contributed equally).

    (2014) Annals of Neurology. 75: 395. PubMed

  • Increased intracellular oxygen radical production in neutrophils during febrileepisodes of PFAPA syndrome

    Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Fasth A, Berg S, Karlsson A*, Brown KL*. (* authors contributed equally).

    (2013) Arthritis & Rheumatism. 65: 2971-2983. PubMed

  • Antimicrobial, Host Defence Peptides and Proteins (version 3)

    Wuerth KC*, Hilchie AL*, Brown KL, Mookherjee N and Hancock R. (* authors contributed equally).

    (2013) In: Encyclopedia of Life Sciences, John Wiley & Sons Ltd. DOI 10.1002/9780470015902.a0001212.pub3.

  • On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL, Wekell P, Karlsson A, Berg S.

    (2011) Proc. Natl. Acad. Sci. U.S.A. 108: E525. PubMed

  • Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and interleukin activated macrophages

    Ruffell B, Poon GF, Lee SS, Brown KL, Tjew S-L, Cooper J and Johnson P.

    (2011) J. Biol. Chem.. 286: 19179-19190. PubMed

  • Host defence peptide LL-37 selectively reduces pro-inflammatory macrophages responses

    Brown KL*, Poon GF*, Birkenhead D, Pena OM, Falsafi R, Dahlgren C, Karlsson A, Bylund J, Hancock REW and Johnson P. (* authors contributed equally).

    (2011) J. Immunol.. 186: 5497-5505. PubMed

  • Galectin-3 aggravates joint inflammation and destruction in antigen-induced arthritis

    Forsman H, Islander U, Andréasson E, Andersson A, Önnheim K, Karlström A, Sävman K, Magnusson M, Brown KL and Karlsson A.

    (2011) Arthritis & Rheumatism. 63: 445-454. PubMed

  • Intracellular Generation of Superoxide by the Phagocyte NADPH-Oxidase; How, Where, and What for?

    Bylund J, Brown KL, Movitz C, Dahlgren C and Karlsson A.

    (2010) Free Radic. Biol. Med.. 49: 1834-1845. PubMed

  • Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL*, Wekell P*, Osla V, Sundqvist M, Sävman K, Fasth A, Karlsson A, Berg S. (* authors contributed equally).

    (2010) BMC Pediatrics. 10: 65. PubMed

  • Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

    Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Finlay BB, Turvey SE, Speert DP and Hancock REW.

    (2010) J. Transl. Med.. 8: 6-17. PubMed

  • G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9

    Gong J-H, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, Cheung CY, Falsafi R, Brinkman FS, Bowdish DM and Hancock REW.

    (2010) Cellular Immunology. 261: 105-113. PubMed

  • Divergent effects on phagocytosis by macrophage-derived oxygen radicals

    Brown KL, Christenson K, Karlsson A, Dahlgren C, Bylund J.

    (2009) J. Innate Immunity. 1: 592-598. PubMed

  • Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

    Amid C, Rehaume LM, Brown KL, Gilbert JGR, Dougan G, Hancock REW and Harrow JL.

    (2009) BMC Genomics. 10: 606-618. PubMed

  • Treating Neonatal Brain Injury - Promise and Inherent Research Challenges

    Sävman K and Brown KL.

    (2010) Recent Pat. Inflamm. Allergy Drug Discov.. 4(1): 16-24. PubMed

  • Galectin-3 functions as an opsonin and enhances macrophage clearance of apoptotic neutrophils

    Karlsson A, Matlak M, Christenson K, Björstad Å, Brown KL, Telemo E, Salomonsson E, Leffler H and Bylund J.

    (2009) Glycobiology. 9: 16-20. Brief Communication. PubMed

  • ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

    Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott M, Falsafi R, Hancock R and Speert DP.

    (2008) Clin. Immunol.. 129: 90-102. PubMed

  • The host defence peptide LL-37 selectively permeabilises apoptotic leukocytes

    Björstad Å, Askarieh G, Brown KL, Christenson K, Önnheim K, Hsin-Ni L, Teneberg S, Maier O, Hoekstra D, Dahlgren C, Davidson DJ and Bylund J.

    (2008) J. Antimicrobial Agents and Chemotherapy. 53: 1027-1038. PubMed

  • Antimicrobial Host Defence Peptides of Human Neutrophils - Roles In Innate Immunity

    Björstad Å, Brown KL, Fu H, Dahlgren C and Bylund J.

    (2008) Anti-Infective Agents in Medicinal Chemistry. 7(3): 155- 168. DOI: 10.2174/187152108784911278..

  • Is Innate Host Defense the Answer?

    Hamill P, Jenssen H, Brown KL and Hancock REW.

    (2008) Curr. Opin. Biotech.. 19: 628-636. PubMed

  • Phagocyte-derived reactive oxygen species as suppressors of inflammatory disease

    Björkman L, Dahlgren C, Karlsson A, Brown KL and Bylund J.

    (2008) Arthritis & Rheumatism. 58(10): 2931-2935. PubMed

  • Complexities of Targeting Innate Immunity to Treat Infection

    Brown KL, Cosseau C, Gardy JL and Hancock R.

    (2007) Trends Immunol.. 28(6): 260-66. PubMed

  • Antimicrobial, Host Defence Peptides and Proteins

    Brown KL, Mookherjee N and Hancock R.

    (2007) In: Encyclopedia of Life Sciences, John Wiley & Sons Ltd..

  • Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NFκB

    Bylund J, MacDonald KL, Brown KL, Mydel P, Collins VL, Hancock R, and Speert DP.

    (2007) Eur. J. Immunol.. 37(4): 1087-96. PubMed

  • IRAK-4 mutation (Q293X): rapid detection, and characterization of defective post-transcriptional TLR/IL1R responses in human myeloid and non-myeloid cells

    Davidson DJ, Currie AJ, Bowdish DME, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Devon RE, Hancock R and Speert DP.

    (2006) J. Immunol.. 177: 8202-11. PubMed

  • Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37

    Brown KL*, Mookherjee N*, Bowdish DME, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers J-P, Bryan J, Brinkman FSL and Hancock R. (* authors contributed equally).

    (2006) J. Immunol.. 176: 2455-64. PubMed

  • Cationic Host Defence (Antimicrobial) Peptides

    Brown KL and Hancock R.

    (2006) Curr. Opin. Immunol.. 18(1): 24-30. PubMed

  • Host defence peptides from invertebrates – emerging antimicrobial strategies

    Hancock R, Brown KL and Mookherjee N.

    (2006) Immunobiology. 211(4): 31-22. PubMed

  • Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide

    Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu J, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FSL, Hokamp K, Potter A, Babiuk LA, Griebel PJ and Hancock R.

    (2006) J. Leukoc. Biol.. 80(6): 1563-74. PubMed