Research

Publications

Original Manuscripts

  • Identification of novel ADA2/CECR1 gene variants and varied clinical phenotype in pediatric vasculitis

    Gibson KM, Morishita K, Dancey P, Moorehead P, Drogmoller B, Shan X, Graham J, Hancock REW, Foell D, Benseler S, Luqmani R, Yeung R, Shenoi S, Bohm M, Rosenberg A, Ross CR, Cabral DA, Brown KL on behalf of the PedVas study group..

    (2019) Arthritis & Rheumatology In Press. Apr 22. PubMed

  • Sterile inflammatory activation of human coronary artery endothelial cells induced by S100A12 is driven by monocyte-derived interleukin 1β

    Armaroli G, Verweyen E, Pretzer C, Kessel K, Hirono K, Ichida F, Okabe M, Cabral DA, Foell D, Brown KL and Kessel C..

    (2019) Arthritis & Rheumatology 71(5): 792-804. PubMed

  • S100A12 and common inflammatory markers improve assessment of disease activity in a PedVas cohort of childhood systemic vasculitis

    Brown KL, Lubieniecki JM, Armaroli G, Kessel K, Gibson KM, Graham J, Liu D, Hancock REW, Ross CJ, Benseler S, Luqmani R, Cabral DA, Foell D and Kessel C on behalf of the PedVas study group..

    (2018) Frontiers in Pediatrics 6: 341. PubMed

  • Elevated mitochondrial reactive oxygen species and cellular redox imbalance in human NADPH-oxidase-deficient phagocytes

    Sundqvist M, Christenson K, Björnsdottir H, Osla V, Karlsson A, Dahlgren C, Speert DP, Anders F, Bylund J* and Brown KL*. (* authors contributed equally).

    (2017) Frontiers Immunology 8: 1828. PubMed

  • Measles Lymphadenopathy in a Child With PFAPA Syndrome

    Jefferson T, Brown KL, Hiebert J, Al-Rawahi GN, Moxham JP, Krajden M, Jassem AN and Tucker LB.

    (2017) Pediatric and Developmental Pathology 21(5): 497-501. PubMed

  • Clinical practice variation and need for pediatric-specific treatment guidelines among rheumatologists caring for children with ANCA-associated vasculitis: an international clinician survey

    Westwell-Roper, C, Lubieniecka JM, Brown KL, Morishita KA, Mammen C, Wagner-Weiner L, Yen E, Li, SC, O’Neil K, Lapidus SK, Brogan P, Cimaz R, Cabral DA for the ARChiVe Investigators Network within the PedVas initiative..

    (2017) Pediatric Rheumatology Online Journal 15(1): 61. PubMed

  • The Importance of Considering Monogenic Causes of Autoimmunity: A Somatic Mutation in KRAS Causing Pediatric Rosai-Dorfman Syndrome and Systemic Lupus Erythematosus

    Ragotte RJ, Dhanrajani A, Pleydell-Pearce J, Del Bel KL, Tarailo-Graovac M, van Karnebeek C, Senger C, McKinnon ML, Seear M, Prendiville JS, Tucker LB, Houghton K, Cabral DA, Guzman J, Petty RE, Brown KL, Tekano J, Wu J, Morishita KA, Turvey SE..

    (2016) Clinical Immunology 175: 143-146. PubMed

  • Temporal characterization of microglia/macrophage phenotypes in a mouse model of neonatal hypoxia-ischemic brain injury

    Hellström Erkenstam N, Fleiss B, Smith P, Wang W, Boström M, Gressens P, Hagberg H, Brown KL, Sävman K, Mallard C..

    (2016) Frontiers in Cellular Neuroscience 10: 286. PubMed

  • Purified hyaluronan and hyaluronan fragments do not stimulate pro-inflammatory cytokine production in dendritic cells or macrophages

    Dong Y, Arif AA, Olsson M, Cali V, Hardman B, Dosanjh M, Lauer M, Midura RJ, Hascall VC, Brown KL, Johnson P..

    (2016) Scientific Reports 6: 36928. PubMed

  • Innate defence regulatory peptide protects against neonatal brain injury

    Boulouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Hagberg H, Hancock REW, Mallard C*, Brown KL*. (* authors contributed equally).

    (2014) Annals of Neurology 75: 395. PubMed

  • Increased intracellular oxygen radical production in neutrophils during febrileepisodes of PFAPA syndrome

    Sundqvist M, Wekell P, Osla V, Bylund J, Christenson K, Sävman K, Fasth A, Berg S, Karlsson A*, Brown KL*. (* authors contributed equally).

    (2013) Arthritis & Rheumatism 65: 2971-2983. PubMed

  • On the road to discovery in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL, Wekell P, Karlsson A, Berg S.

    (2011) Proc. Natl. Acad. Sci. U.S.A 108: E525. PubMed

  • Differential use of chondroitin sulfate to regulate hyaluronan binding by CD44 in inflammatory and interleukin activated macrophages

    Ruffell B, Poon GF, Lee SS, Brown KL, Tjew S-L, Cooper J and Johnson P.

    (2011) J. Biol. Chem. 286: 19179-19190. PubMed

  • Host defence peptide LL-37 selectively reduces pro-inflammatory macrophages responses

    Brown KL*, Poon GF*, Birkenhead D, Pena OM, Falsafi R, Dahlgren C, Karlsson A, Bylund J, Hancock REW and Johnson P. (* authors contributed equally).

    (2011) J. Immunol. 186: 5497-5505. PubMed

  • Galectin-3 aggravates joint inflammation and destruction in antigen-induced arthritis

    Forsman H, Islander U, Andréasson E, Andersson A, Önnheim K, Karlström A, Sävman K, Magnusson M, Brown KL and Karlsson A.

    (2011) Arthritis & Rheumatism 63: 445-454. PubMed

  • Profile of blood cells and inflammatory mediators in periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome

    Brown KL*, Wekell P*, Osla V, Sundqvist M, Sävman K, Fasth A, Karlsson A, Berg S. (* authors contributed equally).

    (2010) BMC Pediatrics 10: 65. PubMed

  • Robust TLR4-induced gene expression patterns are not an accurate indicator of human immunity

    Brown KL, Falsafi R, Kum W, Hamill P, Gardy JL, Davidson DJ, Finlay BB, Turvey SE, Speert DP and Hancock REW.

    (2010) J. Transl. Med. 8: 6-17. PubMed

  • G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9

    Gong J-H, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, Cheung CY, Falsafi R, Brinkman FS, Bowdish DM and Hancock REW.

    (2010) Cellular Immunology 261: 105-113. PubMed

  • Divergent effects on phagocytosis by macrophage-derived oxygen radicals

    Brown KL, Christenson K, Karlsson A, Dahlgren C, Bylund J.

    (2009) J. Innate Immunity 1: 592-598. PubMed

  • Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome

    Amid C, Rehaume LM, Brown KL, Gilbert JGR, Dougan G, Hancock REW and Harrow JL.

    (2009) BMC Genomics 10: 606-618. PubMed

  • Galectin-3 functions as an opsonin and enhances macrophage clearance of apoptotic neutrophils

    Karlsson A, Matlak M, Christenson K, Björstad Å, Brown KL, Telemo E, Salomonsson E, Leffler H and Bylund J.

    (2009) Glycobiology 9: 16-20. Brief Communication. PubMed

  • ROS-deficient monocytes have aberrant gene expression that correlates with inflammatory disorders of chronic granulomatous disease

    Brown KL, Bylund J, MacDonald KL, Song-Zhao GX, Elliott M, Falsafi R, Hancock R and Speert DP.

    (2008) Clin. Immunol. 129: 90-102. PubMed

  • The host defence peptide LL-37 selectively permeabilises apoptotic leukocytes

    Björstad Å, Askarieh G, Brown KL, Christenson K, Önnheim K, Hsin-Ni L, Teneberg S, Maier O, Hoekstra D, Dahlgren C, Davidson DJ and Bylund J.

    (2008) J. Antimicrobial Agents and Chemotherapy 53: 1027-1038. PubMed

  • Enhanced inflammatory responses of chronic granulomatous disease leukocytes involve ROS-independent activation of NFκB

    Bylund J, MacDonald KL, Brown KL, Mydel P, Collins VL, Hancock R, and Speert DP.

    (2007) Eur. J. Immunol. 37(4): 1087-96. PubMed

  • IRAK-4 mutation (Q293X): rapid detection, and characterization of defective post-transcriptional TLR/IL1R responses in human myeloid and non-myeloid cells

    Davidson DJ, Currie AJ, Bowdish DME, Brown KL, Rosenberger CM, Ma RC, Bylund J, Campsall PA, Puel A, Picard C, Casanova JL, Turvey SE, Devon RE, Hancock R and Speert DP.

    (2006) J. Immunol. 177: 8202-11. PubMed

  • Modulation of the Toll-like receptor-mediated inflammatory response by the endogenous human host defence peptide LL-37

    Brown KL*, Mookherjee N*, Bowdish DME, Doria S, Falsafi R, Hokamp K, Roche FM, Mu R, Doho GH, Pistolic J, Powers J-P, Bryan J, Brinkman FSL and Hancock R. (* authors contributed equally).

    (2006) J. Immunol. 176: 2455-64. PubMed

  • Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide

    Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu J, Li Y, Veatch S, Roche FM, Brown KL, Brinkman FSL, Hokamp K, Potter A, Babiuk LA, Griebel PJ and Hancock R..

    (2006) J. Leukoc. Biol. 80(6): 1563-74. PubMed

  • Regulation of hyaluronan binding in myeloid cells by phosphorylated ezrin/radixin/moesin (ERM) proteins

    Brown KL, Birkenhead D, Lai J, Li R and Johnson P.

    (2005) Exp. Cell Res. 303(2): 400-14. PubMed

  • N-acetylglucosamine 6- Osulfotransferases (GlcNAc6STs)-1 and -4 in human monocytes: GlcNAc6ST-1 is implicated in thegeneration of the 6-sulfo N-acetyllactosamine/Lewis x epitope on CD44 and is induced by TNF-alpha

    Tjew S, Brown KL, Kannagi R and Johnson P.

    (2005) Glycobiology 15(7): 7C-13C. PubMed

  • Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes

    Brown KL, Maiti A and Johnson P.

    (2001) J. Immunol. 167(9): 5367-74. PubMed

  • Assaying phage-borne peptides by phage capture on fibrinogen or streptavidin

    Bonnycastle LLC, Brown KL, Tang J and Scott JK.

    (1997) J. Immunol. 378(6): 509-15. PubMed