Neutrophils in Inflammation

Neutrophils are the most abundant immune cell in circulation and have well known roles in inflammation and innate defence. Contrary to this, neutrophils have also been implicated as drivers of damaging inflammatory and immune responses. How neutrophils contribute to inflammation in our bodies that is helpful, and what part they play in rheumatic and other immune-mediated inflammatory diseases (IMID) with persistent, uncontrolled inflammation, is not yet fully understood.

Dr Brown’s past research challenged long-standing dogma that oxygen radicals unequivocally drive tissue damage and inflammation and, in doing so, shed light on a complex interplay between mitochondrial respiration and NADPH-oxidase activity for maintaining cellular homeostasis. 

More recently, the Brown lab described a novel, degranulation-independent mechanism of priming that contributes to a growing body of evidence of (previously underrecognized) heterogeneity among neutrophils. The lab is developing methods to identify and characterize distinct neutrophil subsets as a first step to studying their role(s) in rheumatic diseases.

Chronic Primary Vasculitis

Autoinflammatory Diseases

DADA2 and ADA2 Biology

Neutrophils in Inflammation