We offer research-grade tests for adenosine deaminase 2 activity and Type I Interferon activation that can inform treatment decisions for adult and pediatric patients. For information about sample collection and testing, please contact us.
Adenosine deaminase 2 is an extracellular growth factor and enzyme that breaks down the molecules adenosine and 2’-deoxyadenosine. A “deficiency in ADA2 (DADA2)” causes abnormalities in organs, tissues, blood vessels and/or immune cells, which can be life threatening. We measure ADA2 enzymatic activity in plasma or sera and compare to in-house established normative ranges for healthy children. Reference: Bowers et. al. Pediatr. Rheumatol. Online. J. (2020) 18(1): 54.
Type I interferons (IFN) have important roles in many immune-mediated inflammatory diseases (IMIDs) and are a relatively new therapeutic target. To infer Type I IFN activity, we measure the relative expression of six interferon-stimulated genes (ISGs) in whole blood (collected in Tempus or PAXGene RNA tubes) and calculate an interferon score as per methods by Rice et. al. J. Clin. Immunol. (2017) 37: 123-32.