Primary Vasculitis – Brown Lab

Comparing rituximab and cyclophosphamide in induction therapy for childhood-onset ANCA-associated vasculitis: An ARChiVe registry-cohort study.

Gagne SJ, Sivaraman V, Bosman ES, Klamer B, Morishita KA, Huber A, Orjuela A, Eberhard B, Myrup C, Gerstbacher D, Foell D, Al-Abadi E, McErlane F, Cook K, Wagner-Weiner L, Elder M, Moorthy LN, Dancey P, Yeung R, Khubchandani R, Deepak S, Charuvanij S, Tarvin S, Shenoi S, Tanner T, Brown K, Cabral DA; ARChiVe Investigators Network within the PedVas Initiative. Arthritis Care and Research 2025 Apr;77(4):504-512. PubMed

Editorial: Innate immunity in Vasculitis.

De Souza AWS, Ooi JD, Misra DP, Zhong Y, Brown KL.
(2024) Frontiers in Immunology 15:1432069. PubMed

Evaluating renal disease in pediatric-onset anti-neutrophil cytoplasmic antibody-associated vasculitis: disease course, outcomes, and predictors of outcome

Toor KK, Chen A, Cabral DA, Mammen C, Bosman ES, Shen Y, Bone JN, Noone D, Al-Abadi E, Benseler S, Berard R, Bohm M, Charuvanij S, Cook K, Dancey P, Deepak S, Duffy C, Eberhard B, Elder M, Foell D, Gerstbacher D, Heshin-Bekenstein M, Huber A, James KE, Kim S, Klein-Gitelman M, Martin N, McErlane F, Moorthy LN, Myrup C, Riley P, Shenoi S, Sivaraman V, Tanner T, Tarvin S, Wagner-Weiner L, Yeung RSM, Brown KL, Morishita KA; PedVas Investigators Network. Arthritis & Rheumatology 2024 Dec 3 PubMed

Predictive utility of ANCA positivity and antigen specificity in the assessment of kidney disease in pediatric onset small vessel vasculitis.

Mann S, Bone J, Bosman E, Cabral DA, Morishita KA, Brown KL on behalf of the PedVas Investigator Network
(2024) Rheumatic and Musculoskeletal Diseases (RMD) Open. 10(2):e004315 PubMed

Behcet’s Syndrome – Recent advances to aid diagnosis

Akbaba TH, Ekici M, Çolpak Aİ, Brown KL, Karadağ Ö, Balci-Peynircioglu B.
(2023) Clinical and Experimental Medicine. 23(8):4079-4090. PubMed

Anti-LAMP-2 Antibody Seropositivity in Children with Primary Systemic Vasculitis Affecting Medium- and Large-Sized Vessels.

Akbaba TH, Toor KK, Mann SK, Gibson KM, Alfaro GA, Balci-Peynircioglu B, Cabral DA, Morishita KA, Brown KL on behalf of the PedVas Investigator’s Network.
(2024) International Journal of Molecular Sciences 25(7):3771. PubMed

HLA-DBP1 is associated with ANCA-associated vasculitis in children

Gibson KM, Drogemoller BI, Foell D, Benseler S, Graham J, Hancock REW, Luqmani R, Cabral DA, Brown KL*, and Ross CJ* on behalf of the PedVas investigators network (*equal contribution).
(2023) Arthritis & Rheumatology. 75(6): 1048-1057. PubMed

Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates Type I IFN responsive gene expression

Bowers SM, Sundqvist M, Dancey P, Cabral DA and Brown KL.
(2022) Frontiers Immunology. 13: 995191. doi: 10.3389/fimmu.2022.995191. PubMed

Different disease endotypes in phenotypically similar vasculitides affecting small-to-medium sized blood vessels

Gill EE, Smith ML, Gibson KM, Morishita KA, Lee AHY, Falsafi R, Graham J, Foell D, Benseler S, Ross C, Luqmani R, Cabral DA, Hancock REW, and Brown KL on behalf of the PedVas Initiative Investigators.
(2021) Frontiers in Immunology. 12: 638571. PubMed

Autoantibodies against lysosome associated membrane protein-2 (LAMP-2) in pediatric chronic systemic vasculitis

Gibson KM, Kain R, Luqmani R, Ross CJ, Cabral DA, and Brown KL on behalf of the PedVas Initiative Investigators.
(2021) Frontiers in Immunology. 11: 624758. PubMed

Publications