Autoinflammatory Diseases

Behcet’s Syndrome – Recent advances to aid diagnosis

Akbaba TH, Ekici M, Çolpak Aİ, Brown KL, Karadağ Ö, Balci-Peynircioglu B.
(2023) Clinical and Experimental Medicine. 23(8):4079-4090. PubMed

Hyaluronan promotes intracellular ROS production and apoptosis in TNFα-stimulated neutrophils

Niemietz I and Brown KL.
(2023) Frontiers Immunology. 14: 1032469. PubMed

Elevated adenosine deaminase 2 (ADA2) enzyme activity at the onset of chronic Graft-versus-Host Disease in children

Gibson KM, Drogemoller BI, Foell D, Benseler S, Graham J, Hancock REW, Luqmani R, Cabral DA, Brown KL*, and Ross CJ* on behalf of the PedVas investigators network (*equal contribution).
(2023) Arthritis & Rheumatology. 75(6): 1048-1057. PubMed

Pathogenic variant c.1052T>A (p.Leu351Gln) in adenosine deaminase 2 impairs secretion and elevates Type I IFN responsive gene expression

Bowers SM, Sundqvist M, Dancey P, Cabral DA and Brown KL.
(2022) Frontiers Immunology. 13: 995191. doi: 10.3389/fimmu.2022.995191. PubMed

Children with systemic autoinflammatory diseases have multiple, mixed ethnicities that reflect regional ethnic diversity

Tucker LB, Niemietz I, Mangat P, Belen M, Tekano J, Cabral DA, Morishita KA, Guzman J, Human A, Houghton K, Chan M, Petty RE, Sundqvist M, Brown KL
(2021) Clinical and Experimental Rheumatology. 39(5): Suppl. 132. PubMed

Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group

Amarilyo G, Rothman D, Manthiram K, Edwards KM, Li SC, Marshall GS, Yildirim-Toruner C, Haines K, Ferguson PJ, Lionetti G, Cherian J, Zhao Y, DeLaMora P, Syverson G, Nativ S, Twilt M, Michelow IC, Stepanovskiy Y, Thatayatikom A, Harel L, Akoghlanian S, Tucker L, Marques MC, Srinivasalu H, Propst EJ, Licameli GR, Dedeoglu F, and Lapidus S; CARRA PFAPA Consensus Treatment Plan Workgroup.
(2020) Pediatric Rheumatology. 18(1): 31. PubMed

Hyaluronan primes the oxidative burst in human neutrophils

Niemietz I, Moraes AT, Sundqvist M, and Brown KL.
(2020) Journal of Leukocyte Biology. 108(2): 705-713. PubMed

Adenosine Deaminase 2 activity negatively correlates with age during childhood

Bowers SM, Gibson KM, Cabral DA, and Brown KL.
(2020) Pediatric Rheumatology. 18(1): 54. PubMed

Complexity in unclassified auto-inflammatory disease: A case report illustrating the potential for disease arising from the allelic burden of multiple variants

Tucker LB , Lamot L, Niemietz I, Chung BK, Cabral DA, Houghton K, Petty RE, Morishita KA, Rice GI, Turvey SE, Gibson WT, and Brown KL.
(2019) Pediatric Rheumatology. 17(1): 70. PubMed

Comparable type I interferon score determination from PAXgene and Tempus whole blood RNA collection and isolation systems

Lamot L, Niemietz I, and Brown KL.
(2019) BMC Research Notes. 12(1): 511. PubMed

Publications